Psychedelic Therapy

Revolutionizing Healthcare: Gateway Sciences is at the Forefront of Progress in Medicine

PSYCHEDELIC THERAPY

What is Psychedelic Therapy?

Psychedelic therapy is the psychiatric practice involving ingesting psychedelic substances to alleviate trauma, aid in treating mental illnesses and help relieve physical pain. Alongside assistance from substances, trained therapists also employ psychotherapy and psychiatry, such as cognitive-behavioural therapy (CBT).

The most common psychedelic substances used in medicine today are Ketamine, Ibogaine, MDMA, and Psilocybin. Psychedelic therapy incorporates the natural properties of these substances. It integrates them with synthetic chemicals to make the treatment safe for all who require it.

Through decades of research and hundreds of clinical studies, psychedelic therapy has been found to be highly effective in aiding the treatment of various disorders such as PTSD, anxiety, depression, addictions, and chronic physical pain, among others.

Patients who have not experienced any improvement through conventional therapy have reported a drastic change through psychedelic-assisted treatments. In addition, it has been extensively reported and documented that people are able to live better, self-actualized, and healthier lives after undergoing guided psychedelic sessions.

Types of Psychedelic Therapy

Each human mind deals with psychedelics differently. No two humans experience the same effects, although there are thematic similarities. As a result of this variation in treatment, medical professionals engaged in psychedelic therapy employ many different psychiatric methods to treat patients suffering from a myriad of different diseases. Gateway Sciences specializes in the following types of psychedelic therapy.

Ibogaine Therapy: Ibogaine is a naturally occurring substance that has psychoactive properties. It has been known to be effective in treating addictions. Overcoming addiction is a complicated process and Ibogaine has proven to be effective in this regard.[1]

MDMA Therapy: MDMA, also known as ecstasy, has recently been adopted by medicinal firms to treat PTSD. MDMA had been outlawed in the USA until 2017, when awareness campaigns led to researchers studying the compound and its effects in aiding those suffering from mental ailments.[2]

Psilocybin Therapy: Psilocybin is the primary substance found in Psilocybe cubensis mushrooms and is the source of the sensations people experience after ingesting them. It has been reported to be effective at treating symptoms of anxiety and depression.[3][4] Patients suffering from addiction and OCD report favorable results after consuming psilocybin.[5][6]

Ketamine Therapy: Ketamine is one of the most widely used psychedelics in modern-day medicine. It is effective in aiding the treatment of a wide variety of mental illnesses, including, but not limited to PTSD, OCD, ADHD, anxiety, and depression.[7][8][9]

Benefits vs Risks

Research into the medical applications of psychedelics and their usage in psychiatry has increased exponentially. However, many still are concerned about the potentially harmful side effects of consuming psychedelics.
At Gateway Sciences, we believe in safety and responsibility. Under clinical conditions and in a controlled environment, any risks associated with using psychedelic medicines can be significantly mitigated.

Benefits

  • Psychedelics can directly affect the serotonin transmitters in the brain, initiating the feeling of relaxation and happiness and erasing symptoms of depression
  • The introspective experiences induced by psychedelics can lead to patients healthily coping with PTSD
  • Proper psychedelic therapy can help patients stay connected and increase social awareness, which can mitigate the feelings of anxiety
  • Psychedelics can effectively treat addictions of alcohol, opiates, and other substances, which are often difficult to overcome through conventional therapy
  • Psychedelic therapy has proven effective at treating treatment-resistant mental ailments
  • Psychedelic medicine often has no side effects related to traditional antidepressants, such as feelings of apathy
  • Psychedelics can initiate a trance in which the user can undergo a higher state of consciousness which can help them overcome trauma and become more self-actualized.

Risks

  • Patients run the risk of potential addiction if they are consumed without supervision or guidance
  • Improper medicinal use can worsen symptoms of mental ailments
  • Self-medication can be potentially harmful as users can take improper doses of psychedelic medicine
  • Usage of psychedelics can lead to psychosis in some patients due to otherworldly experiences

[10][11][12]

A Brief History of Psychedelics for Healing

Psychedelics have a long and convoluted history in terms of their applications. Although their usage can be traced back to prehistoric times, most research and study have been conducted in the 21st century.

Prehistoric Times
There is evidence of the consumption of psychedelics since prehistoric times. For example, shamans used it for religious rituals, and warriors consumed it owing to its psychoactive nature.

1940s
LSD is discovered and mass manufactured.

1950s – Early 1960s
More research is done on psychedelics, including their applications in medicine. Over 1,000 peer-reviewed papers are published on the subject.

Mid 1960s – 1970s
Research into psychedelics virtually stops due to concerns about potentially harmful side effects such as addiction. The Controlled Substances Act outlaws them.

1980s
The applications of psychedelics in therapy are discontinued worldwide.

2000s
The advent of new technology in medicine, such as sophisticated brain scan technologies, leads to a renewal in applications of psychedelics in healing mental ailments as evidence is collected proving their effectiveness.

2010s
More tests are conducted on the applications of psychedelics in healing, and the results are promising. Psychedelics are shown to be effective at combating treatment-resistant ailments such as chronic depression and anxiety.

2020 – Beyond
Many research centers are currently working on the advancement of psychedelic therapy and treatment. Psychedelics such as ketamine are now commonly prescribed to heal ailments such as depression.

Prevalence and Acceptance

Since interest in psychedelics as a medicinal drug has only recently been renewed, they have not gained widespread acceptance yet. Psychedelic treatment is prescribed to those suffering from treatment-resistant ailments to significant effect. However, the taboo surrounding psychedelics is still present regardless.

Articles in publications such as The New York Times have boosted interest in psychedelics in the previous decades and facilitated their acceptance in the field of medicine. In 2019, the FDA labeled psilocybin-assisted therapy as a “breakthrough therapy” due to the promising results.[15] Although the usage of psychedelics is gaining acceptance in mainstream medicine, there are still many areas and applications which must be thoroughly researched first.

Gateway Sciences has a team of researchers and experts that are constantly unraveling the medical mysteries of psychedelics. We believe in destigmatizing the concept of psychedelics in healthcare as they have proven effective so far in treating mental ailments, despite the social taboo surrounding them. Our researchers believe psychedelics can help unshackle us from the trauma and ailments that are holding us back and allow us to embrace a higher level of living and self-actualization.

Applications of Psychedelic Therapy

So far, research into psychedelics has shown that they effectively treat a multitude of disorders and ailments. The following are the few areas where psychedelics were utilized to promising effects.

Curing Addiction: Studies found that psychedelics such as LSD were instrumental in helping patients cure their addictions to alcohol and other such substances. Psilocybin and Ibogaine are also noted to have anti-addiction properties, although more research must be done in this regard.[16][17]

Anxiety and Depression: Due to the natural calming effect of psychedelics, research indicates that they mitigate the symptoms of anxiety and mood disorders. Many studies have been done in this regard. The FDA has approved psilocybin to treat depression, calling it “a breakthrough therapy.” Psychedelics have been reported to be greatly effective in treating the anxiety and depression of those suffering from terminal illnesses.[15][18]

Post-Traumatic Stress Disorder: MDMA or ecstasy has been known to aid in treating patients who have severe PTSD. It has been noted to be effective in cases of treatment-resistant mental ailments as well.[19][20]

Life-Changing Experiences: It has been reported that many patients who underwent psychedelic treatment claimed that the experience left a lasting impact on their lives. Psychedelic experiences can detach the user from their bodies and allow them to look at their lives from a higher level of consciousness. This leads to introspection later and eventually massive change in their personality and mood.[21]

Psychedelic Therapy vs Psycholytic Therapy

When considering psychedelic therapy, patients are often given the option of undergoing conventional psychedelic therapy and psycholytic therapy. Both have their specific benefits, but some patients might be more receptive to one form of treatment than the other.

Psychedelic Therapy: In this form of therapy, patients are given a substantial dose of the psychedelic at small intervals to induce out-of-body or transcendental experiences. A patient spends most of the treatment with their eyes closed while lying down as the effects of the drugs begin to take hold. Conversation between the therapist and patient is minimal. Psilocybin and ayahuasca are the drugs of choice in this regard due to their potency. This treatment aims to bring about ego dissolution and initiate introspection within the patient, help overcome addiction and bring about a new understanding of life, along with the necessary motivation.

Psycholytic Therapy: Psycholytic therapy incorporates minimal doses of psychedelics at intervals of 1-2 weeks. A trained therapist is present throughout the treatment and helps the patient overcomes their ailment while staying conscious. Psychedelics such as ketamine are given to the patient in small doses in greater frequency. This treatment aims to treat patients suffering from psychosomatic disorders such as migraines, hypertension, etc.

Other Forms of Psychedelic Therapy

Aside from the two primary forms, multiple other types of treatment programs do exist, each of them incorporating the applications of psychedelics differently for a particular outcome.

Combination: This treatment was formulated by Czech psychiatrist Stanislav Grof. It combines the two forms of psychedelic therapy. Also, it incorporates Holotropic breathwork, which enables patients to enter other states of consciousness. This treatment was instrumental in healing buried childhood trauma.[22][23]

Anaclitic Therapy: This type of treatment attempts to heal buried trauma. The main aim is to allow the patient to relive the trauma to overcome it through psychedelics.[24]

Hypnodelic Therapy: This combines psychedelic therapy with hypnosis. Psychedelics such as LSD are administrated when the patient has undergone hypnosis to initiate a trance. This method is reported to be more effective than hypnosis and psychedelic therapy individually.[25]

Shamanic Therapy: This type is perhaps the oldest among psychedelic treatments. Shamans, rather than clinical physiatrists, allow the patient to consume naturally growing psychedelics such as psilocybin and mushrooms to heal mental illnesses.[26]

Effectiveness of Psychedelic Therapy

Psychedelic therapy has been reported to have been highly successful in treating mental ailments, even those which were resistant to treatment. For example, in a study by Johns Hopkins Medicine [Davis & Barrett et al. 2020]*, researchers conducted psychedelic therapy on adults who were suffering from major symptoms of depression. Psilocybin was incorporated along with conventional therapy during the study. As a result, most of the patients reported significant improvements in mood and the erasure of symptoms.

Psychedelic therapy has shown to be quite efficient at treating mental disorders, more so than conventional medicines. This is because the side effects such as apathy induced by conventional antidepressants are virtually absent in psychedelics. The experiences that psychedelics induced have helped patients heal childhood trauma, treat PTSD, and overcome addiction.[27][28][29]
The exact effectiveness and accuracy of psychedelics in medical science are still undergoing research.

However, the results so far are promising enough that many medical facilities are employing the usage of psychedelics to assist in therapy.

Elimination of mental ailments Healing buried trauma Overcoming addiction Mitigating treatment-resistant diseases
Usage of psychedelics along with therapy has helped patients overcome depression, anxiety, and PTSD Psychedelics help to initiate a state of self-actualization which can assist in overcoming childhood trauma Psychedelic treatment and therapy help patients overcome an addiction to alcohol, smoking, and other harmful substances Psychedelic treatment has helped patients to overcome ailments that conventional medicines were unable to achieve.

Modern Day Research on Psilocybin Therapy

Research to discover and develop new applications for psilocybin therapy, and to further ascertain the various effects of the substance, continue apace around the world.

It has been further augmented in recent years—even when the treatment remains illegal in most countries. The US FDA claims it is a ‘breakthrough therapy’ for patients suffering from anxiety, depression, obsessive-compulsive disorder [OCD], alcohol addiction, and drug-related disorders.[3]

Several institutions, including Johns Hopkins University, the University of California, and the Icahn School of Medicine at Mount Sinai, have invested significant amounts—of both time and money—in research. They intend to form a more comprehensive understanding of the substance.[11][12][13]

In a study published in 2020, around 71% of the patients who took psilocybin reported a huge decrease in depressive symptoms. After a month, half of the patients entered remission.[14]

Gateway Sciences is committed to offering our patients the safest and most credible treatment methods to be found worldwide. We acknowledge the vast potential of psilocybin and its effects. We also understand that if used in a controlled and safe environment, any potential risks associated with it can be mitigated to an extent where treatment is perfectly safe.

Effectiveness of Psilocybin Therapy

The indigenous tribes of South America have employed psilocybin therapy for centuries. Its effectiveness varies widely, however, in the treatment of one ailment to another. In addition, the substance affects each user differently. As a result, further research and study are required for more comprehensive knowledge of its effects.

Based on clinical studies done under controlled circumstances, psilocybin is known to be effective at treating [1] [2] anxiety, depression, and alcohol dependence, and addiction in patients.[3] It helps serotonin flow in the brain, thus generating feelings of joy and contentment even in those suffering from chronic depression.

The substance should always be ingested under the care of expert medical practitioners to reduce the risks of adverse effects. [17]

Patients are requested to ingest a psilocybin capsule and put on an eye mask to limit distractions during treatment. The supervising expert present ensures nothing is amiss. A session lasts for around 6-8 hours, after which a follow-up integration session is conducted where the patient and the expert make progress through conversation. [18]

Where to Begin?

Gateway Sciences goal is to become the market leader in the treatment of all ailments. We specialize in optimal medicine years ahead of conventional options.

Do not hesitate to call us for advice or consultation HERE.

Call Us: 1 (424) 330-0000

Address: Gateway Clinics Santa Monica, 1205 1/2 Montana Avenue, Santa Monica, CA 90403

References

  1. Noller GE, Frampton CM, Yazar-Klosinski B. Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study. Am J Drug Alcohol Abuse. 2018;44(1):37-46. doi: 10.1080/00952990.2017.1310218. Epub 2017 Apr 12. PMID: 28402682.
  2. Mithoefer MC, Feduccia AA, Jerome L, Mithoefer A, Wagner M, Walsh Z, Hamilton S, Yazar-Klosinski B, Emerson A, Doblin R. MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology (Berl). 2019 Sep;236(9):2735-2745. doi: 10.1007/s00213-019-05249-5. Epub 2019 May 7. PMID: 31065731; PMCID: PMC6695343.
  3. Johnson MW, Griffiths RR. Potential Therapeutic Effects of Psilocybin. Neurotherapeutics. 2017 Jul;14(3):734-740. doi: 10.1007/s13311-017-0542-y. PMID: 28585222; PMCID: PMC5509636.
  4. Vargas AS, Luís , Barroso M, Gallardo E, Pereira L. Psilocybin as a New Approach to Treat Depression and Anxiety in the Context of Life-Threatening Diseases-A Systematic Review and Meta-Analysis of Clinical Trials. Biomedicines. 2020 Sep 5;8(9):331. doi: 10.3390/biomedicines8090331. PMID: 32899469; PMCID: PMC7554922.
  5. Moreno FA, Wiegand CB, Taitano EK, Delgado PL. Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. J Clin Psychiatry. 2006 Nov;67(11):1735-40. doi: 10.4088/jcp.v67n1110. PMID: 17196053.
  6. Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015 Mar;29(3):289-99. doi: 10.1177/0269881114565144. Epub 2015 Jan 13. PMID: 25586396.
  7. Phillips JL, Norris S, Talbot J, Birmingham M, Hatchard T, Ortiz A, Owoeye O, Batten LA, Blier P. Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial. Am J Psychiatry. 2019 May 1;176(5):401-409. doi: 10.1176/appi.ajp.2018.18070834. Epub 2019 Mar 29. PMID: 30922101.
  8. Albott CS, Lim KO, Forbes MK, Erbes C, Tye SJ, Grabowski JG, Thuras P, Batres-Y-Carr TM, Wels J, Shiroma PR. Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression. J Clin Psychiatry. 2018 May/Jun;79(3):17m11634. doi: 10.4088/JCP.17m11634. PMID: 29727073.
  9. Phillips JL, Norris S, Talbot J, Hatchard T, Ortiz A, Birmingham M, Owoeye O, Batten LA, Blier P. Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression. Neuropsychopharmacology. 2020 Mar;45(4):606-612. doi: 10.1038/s41386-019-0570-x. Epub 2019 Nov 23. PMID: 31759333; PMCID: PMC7021716.
  10. Tupper KW, Wood E, Yensen R, Johnson MW. Psychedelic medicine: a re-emerging therapeutic paradigm. CMAJ. 2015;187(14):1054-1059. doi:10.1503/cmaj.141124
  11. Robertson K, Ditzell J (medical reviewer). Psychedelic therapy is having a moment – here’s what you need to know. Healthline. 2021 May.
  12. Villines Z, Jelinek J (medical reviewer). What to know about psychedelic therapy. Medical News Today. 2021 June.
  13. Williams B. Psychedelic drugs: Lessons from ketamine and psilocybin. Psychiatry Advisor. 2020 October.
  14. Ly C, Greb AC, et al. Psychedelics Promote Structural and Functional Neural Plasticity. Cell reports vol. 23,11 (2018): 3170-3182. doi:10.1016/j.celrep.2018.05.022
  15. Aday JS, Bloesch EK, Davoli CC. 2019: A year of expansion in psychedelic research, industry, and deregulation. Drug Science, Policy and Law. January 2020. doi:10.1177/2050324520974484
  16. Krebs TS, Johansen P-Ø. Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. Journal of Psychopharmacology. 2012;26(7):994-1002. doi:10.1177/0269881112439253
  17. Koenig X, Hilber K. The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation. Molecules. 2015; 20(2):2208-2228. https://doi.org/10.3390/molecules20022208
  18. Schimmel N, Breeksema JJ, Veraart JKE, van den Brink W, Schoevers RA. Psychedelics for existential distress in terminally ill patients. Tijdschr Psychiatr. 2020;62(8):659-668. Dutch. PMID: 32816294.
  19. Hull M, Hairston S (medical reviewer). MDMA and Depression. 2020 November.
  20. Mithoefer MC, Grob CS, Brewerton TD. Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA. Lancet Psychiatry. 2016 May;3(5):481-8. doi: 10.1016/S2215-0366(15)00576-3. Epub 2016 Apr 5. PMID: 27067625.
  21. Millière R, Carhart-Harris RL, Roseman L, Trautwein FM, Berkovich-Ohana A. Psychedelics, Meditation, and Self-Consciousness. Front Psychol. 2018 Sep 4;9:1475. doi: 10.3389/fpsyg.2018.01475. PMID: 30245648; PMCID: PMC6137697.
  22. Grof S. Psychology of the Future: Lessons from Modern Consciousness Research. Albany, NY: State University of New York Press, 2000
  23. Miller T, Nielsen L. Measure of Significance of Holotropic Breathwork in the Development of Self-Awareness. J Altern Complement Med. 2015 Dec;21(12):796-803. doi: 10.1089/acm.2014.0297. Epub 2015 Nov 13. PMID: 26565611; PMCID: PMC4677109.
  24. Claude RN, Bernard B. Anaclitic Therapy. AJN, American Journal of Nursing: July 1958 – Volume 58 – Issue 7 – p 989-991
  25. Levine J, Ludwig Am. The hypnodelic treatment technique, International Journal of Clinical and Experimental Hypnosis, 1966, 14:3, 207-215, DOI: 10.1080/00207146608412963
  26. Dobkin de Rios M. What we can learn from shamanic healing: brief psychotherapy with Latino immigrant clients. Am J Public Health. 2002 Oct;92(10):1576-8. doi: 10.2105/ajph.92.10.1576. PMID: 12356595; PMCID: PMC1447282.
  27. Baumeister D, Barnes G, Giaroli G, Tracy D. Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles. Ther Adv Psychopharmacol. 2014 Aug;4(4):156-69. doi: 10.1177/2045125314527985. PMID: 25083275; PMCID: PMC4104707.
  28. Carhart-Harris RL, Goodwin GM. The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future. Neuropsychopharmacology. 2017 Oct;42(11):2105-2113. doi: 10.1038/npp.2017.84. Epub 2017 Apr 26. PMID: 28443617; PMCID: PMC5603818.
  29. Davis AK, Barrett FS, May DG, et al. Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(5):481–489. doi:10.1001/jamapsychiatry.2020.3285
  30. Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. The Journal of nervous and mental disease, 202(7), 513–520. https://doi.org/10.1097/NMD.0000000000000113